I think the most obvious issues were...
Pass Protection: Luck was sacked 4 times and was hit way too many times. He often didn't have enough time to set his feet.
Pass Rush: Pryor had all day to throw.
Defending against the read option: Couldn't stop Pryor.. and when they did get to him the defense couldn't bring him down.
Coaching: Didn't really notice any half time adjustments? Play calling seemed to vanilla. The team just seemed to be really unprepared to defend against Pryor..?
Not utilizing players properly... I guess this can fall into the coaching category, but Hilton didn't see the field enough. Fleener/Allen were hardly targeted. Why even have these TE's on the roster?
Other: Any other problems you can think of?