I haaaaaate Kanye, but dude's crazy talented. It's not a traditionally talented type of deal with regard to being creative with a melody/notes/whatever, but he's changed how we listen to music. That's almost as impressive as being as musically brilliant as someone like Jack White.
Now, none of these guys are on the level of someone who is classically trained (and many of those musicians couldn't fit into the popular music world), but they're heads and shoulders above their peers.
One name I'd throw out there is Trent Reznor. He's not particularly heavily played, but damn near everyone when I was in HS knew his name.