The Lakers are currently 3 games under .500 and there are ten teams in the West alone with better records than the Lakers (not to mention Portland who has the same record). Wish Nash out two more weeks at least, Blake out two more months at least, and Pau... who knows how long he's going to be out and if he's ever even going to suit up with the Lakers again, it's hard to say when the Lakers will be at full force. Certainly no sooner than January, and then Nash still has to work his way into the system (he hasn't had much time with these guys).
What is LA's record going to be by then? Sure, they'll likely beat the Cavs and Wizards (though I wouldn't put money on it), but that won't even get them to .500! Before December is up they will have played two games with the Knicks, neither of which I expect them to win considering how they've faired against some sub-.500 teams, and games against the 76ers and Warriors. The Lakers will likely be between 3-6 games under .500 when January rolls around.
The Lakers have one of the most talented rosters the league has ever seen on paper, but health issues are going to keep them from putting their best porduct on the floor at least until January, and by that time the 10 teams that have records better than LA, will have time to put more distance between themselves and the Lakers, meaning the second half of the season the Lakers will not only have to play .500 ball, but they'll have to play better than that just to catch up to the other western conference playoff teams.
Are the Lakers in serious jeopardy of missing the playoffs?
And please note, I did not point that finger at any one person, be it player or coach, and nor did I intentionally leave the letter "D" out of anybody's name ;-)