As long as the core remains the same (Lee,Curry,Bogut) the chemistry shouldn't be affected by acquiring a bench player.
Can't trade Biedrins for Blatche though because Blatche's salary is under $1 million and Biedrins is $9 million. Trading for Blatche though would be a nice piece. He can really score and he's got size. No doubting his talent.