Even without his Venom, he’s still labeled as a human at his highest peak for physical and mental perfection in all respects. Not only that but Bane is one of the smartest humans on the planet capable of deducing Batman's identity with little support or investigation.
Vulcan is an Omega level mutant who can manipulate all
forms of energy. Professor X called him the most powerful energy manipulator he has ever come across. His Psionic abilities are also incredibly powerful allowing him to control the psionic powers of others including Cyclops's energy beams, and Adam Warlock's spells.
Doomsday is one of he most powerful beings in the universe and most well known for KILLING SUPERMAN
. He's able to adapt against anything that can hurt him, and even if he does manage to die, he is ressurected without that weakness. He's immune to telepathic attacks and has bone projectiles that he can shoot at his enemies.
4. The Hulk
Hulk Smash! The Hulk is the strongest being in the game, the angrier he gets the stronger he gets. Not to mention his healing abilities are some of the strongest as well. He's super fast, and can jump so high he can achieve stable orbit.
5. The Mandarin
The Mandarin is one of the most cunning, and manipulative leaders in all of comics. It was he who originally engineered Tony Stark's kidnapping and pulled many of the strings of worldwide activities. He is an extremely powerful martial artist, strong enough to break the Iron Man suit. He is powered by 10 extremely powerful rings that give him an absurd amount of powers LIST
Energy Based Constructs
Phasing / Ghost
Now the best part about the Mandarin is that has the capabilities to control the Hulk, however he has been thwarted by the worlds heroes. Now that he has preparation time, he will be able to control the Hulk with ease, and will use his control powers on Doomsday as well. Thus corralling two of the most powerful beings in the game into controllable and easily usable weapons.
6. Emma Frost
The former White Queen of the Hellfire Club. Emma Frost is an extrmely powerful Omega level mutant. She she has the ability to turn herself compeltely into diamond. The speed it takes for her to transform in and out of her diamond form is almost instantaneous, being described as happening within a hundredth of a second. While she is not in diamond form, she is a powerful telepath. She can use mind control, shoot 'psi-beams', induce paralysis and can even kill solely via her mind. She is extremely powerful and can take on just about anyone.
Circe is an amazingly powerful soceress with the abilities to bend reality itself. She can alter memories, and bend objectes into whatever she wants. She can teleport and has the ability to launch destrutive magical blasts at people, and can put up magical shields.
Carnage is symbiote who is intensely powerful. He's extremely strong and fast and has the abilities to shoot projectiles from his hands. His symbiote is special as well, being stronger than Venom's. It also has the abilities to infect others and control them as it has done to Wolverine, Captain America, the Thing, and Hawkeye.
Desparo is a powerful telepath, who as at times enslaved the Justice League with his mental abilities. He's also super strong as well, and can take serious physical punishment. His mental abilites are strong enough to control the Martian Manhunter, known as one of the strongest telepaths. He also has strong reality warping powers, and can warp energy and matter. He can also possess others and will retain his powers.
Parasite is a former Janitor exposed to radiation who developed powers that allow him absorb energy from others. He can also absorb the life forces of others and can absorb the DNA of others giving him the powers of metahumans. He's also quite strong.
Possesses the ability to shapeshift and change the form of their bodies. This gives them the power to look like any person they chose as well create weapons out of their limbs to attack enemy and also melt. More recent powers added to Clayface's mantle is the ability to melt objects by just looking at them and also being able to pass on powers to ordinary humans. Because of Clayface's body nearly all physical attacks are useless. Clayface can also use his body to smother victims until lifeless.